Effects of low-intensity pulsed ultrasound on fractures, pseudoarthrosis, and bone consolidation in adults
a literature review
Keywords:
Non-invasive therapy, Bone repair, Tissue regenerationAbstract
Ultrasound therapy has been used in bone repair; however, there are still controversies regarding its effects and application parameters, and its use is often neglected or based solely on practical experience. Thus, a study that investigates the existing literature on the use of ultrasound in bone healing is of great importance to the academic community, as it can describe the relevant parameters and effects and provide evidence to support the use of this therapy in clinical practice. In addition, this approach may represent an evidence-based therapeutic alternative for the treatment of impaired bone healing. In this context, therapeutic ultrasound has been explored as a non-invasive option with the potential to accelerate bone healing, reduce recovery time, and improve functional outcomes. From this perspective, this study aimed to elucidate the therapeutic effects of ultrasound use on the bone healing process in adult patients with fractures or pseudoarthrosis. This is an integrative literature review on the use of therapeutic ultrasound in the treatment of fractures in adults, characterized as exploratory and descriptive, with a qualitative approach. Low-intensity pulsed ultrasound therapy was shown to be safe and effective, promoting endochondral bone and callus formation, as well as reducing healing time in cases of fractures or pseudoarthrosis. Therefore, low-intensity pulsed ultrasound represents a promising therapeutic approach with the potential to support the treatment of fractures, pseudoarthrosis, and impaired bone healing. However, further studies are needed to contribute to the standardization of the parameters for the use of this therapy.
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References
Amancio, A. C. G. et al. Estimulação ultrassônica da integração de enxertos de pele total: estudo experimental em coelhos. Acta Ortopédica Brasileira, v.14, n.5, p. 276-279, 2006.
Bawale, R. et al. Experience of an isolated use of low-intensity pulsed ultrasound therapy on fracture healing in established non-unions: a prospective case series. Journal of Ultrasound, v. 24, p. 249-252, 2021.
Biglari, B. et al. Failed treatment of long bone nonunions with low intensity pulsed ultrasound. Archives of orthopaedic and trauma surgery, v. 136, p. 1121-1134, 2016.
Busse, J. W. et al. Trial to re-evaluate ultrasound in the treatment of tibial fractures (TRUST): a multicenter randomized pilot study. Trials, v. 15, p. 1-8, 2014.
Busse, J. W. et al. Re-evaluation of low intensity pulsed ultrasound in treatment of tibial fractures (TRUST): randomized clinical trial. bmj, v. 355, 2016.
Farkash, U. et al. Low-intensity pulsed ultrasound for treating delayed union scaphoid fractures: case series. Journal of orthopaedic surgery and research, v. 10, p. 1-7, 2015.
Fontes-Pereira, A. J. et al. Efeito do ultrassom terapêutico de baixa intensidade em fratura induzida em tíbia de ratos. Acta Ortopédica Brasileira, v. 21, n. 1, p. 18–22, 2013.
Liu, Y. et al. Ultrasound treatment for accelerating fracture healing of the distal radius. A control study. Acta Cirúrgica Brasileira, v. 29, p. 765-770, 2014.
Marconi, M. A; Lakatos, E. M. Fundamentos de metodologia científica. 8. ed. São Paulo: Atlas, 2019.
Nolte, P. et al. Heal rate of metatarsal fractures: A propensity-matching study of patients treated with low-intensity pulsed ultrasound (LIPUS) vs. surgical and other treatments. Injury, v. 47, n. 11, p. 2584-2590, 2016.
Nozaka, K. et al. Combined effect of teriparatide and low-intensity pulsed ultrasound for nonunion: a case report. BMC Research Notes, v. 7, p. 1-5, 2014.
Palanisamy, P. et al. Low‐Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing: A Review. Journal of Ultrasound in Medicine, v. 41, n. 3, p. 547-563, 2022.
Povlsen, S. D.; Povlsen, B. Low-intensity pulsed ultrasound treatment as an alternative to vascular bone graft surgery for a 5-year-long ulnar non-union in a patient with haemochromatosis. Case Reports, v. 2015, p. bcr2015211950, 2015.
Salem, K. H.; Schmelz, A. Low-intensity pulsed ultrasound shortens the treatment time in tibial distraction osteogenesis. International orthopaedics, v. 38, p. 1477-1482, 2014.
Silva, A. F. e et al. Aplicabilidade do ultrassom terapêutico em fraturas com atraso na consolidação: uma revisão integrativa. Maringá: Rev. UNINGÁ, v. 57, n. 1, p. 1-10, 2020.
Silva, K. D. A. da; Luna, P. M. de; Fernandes, N. L.; Durante, R. A. Atuação fisioterapêutica no tratamento de fratura por estresse por Overtraining/ Physiotherapy activation without Overtraining stress fracture treatment. Brazilian Journal of Development, [S. l.], v. 7, n. 1, p. 10276–10293, 2021.
Simpson, A. H. R. W. et al. Low-intensity pulsed ultrasound does not influence bone healing by distraction osteogenesis: a multicentre double-blind randomised control trial. The bone & joint journal, v. 99, n. 4, p. 494-502, 2017.
Song, M. H. et al. Low-intensity pulsed ultrasound enhances callus consolidation in distraction osteogenesis of the tibia by the technique of lengthening over the nail procedure. BMC musculoskeletal disorders, v. 20, p. 1-8, 2019.
Tarride, J. E., et al. Low-intensity pulsed ultrasound for treatment of tibial fractures. The Bone & Joint Journal, v. 99-B, n. 11, 2017.
Teixeira, D. S. C. et al. Análise da resposta dos anti-inflamatórios não-esteroidais no reparo ósseo em pacientes submetidos à distração osteogênica. Revista Contemporânea, v. 3, n. 9, 2023.
Waris, C. D. A. e et al. A eficácia do ultrassom terapêutico pulsado na consolidação de fraturas. Revista Paraense de Medicina - v.27, n. 3, 2013.
Zhang, P. et al. Fracture nonunion treated with low-intensity pulsed ultrasound and monitored with ultrasonography: a feasibility study. BioMed Research International, 2021.
Zura, R. et al. A cohort study of 4,190 patients treated with low-intensity pulsed ultrasound (LIPUS): findings in the elderly versus all patients. BMC musculoskeletal disorders, v. 16, p. 1-10, 2015a.
Zura, Robert et al. Treatment of chronic (> 1 year) fracture nonunion: heal rate in a cohort of 767 patients treated with low-intensity pulsed ultrasound (LIPUS). Injury, v. 46, n. 10, p. 2036-2041, 2015b
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